Divergent effects of dithiocarbamates on AP-1-containing and AP-1-less NFAT sites

Inhibitory effects of deferoxamine on UVB-induced AP-1 transactivation.

Production of reactive oxygen species (ROS) by iron can contribute directly to DNA and protein damage and may contribute to cell signaling and proliferation. We have examined the effects of the iron(III) chelator deferroxamine (DFO) and iron (FeCl(3)) on UVB (290-320 nm)-induced activator protein 1 (AP-1) signaling. The ability of DFO to inhibit UVB-induced AP-1 transactivation was tested in a ...

Luciferase reporter gene vectors that lack potential AP-1 sites.

Reporter gene expression vectors have streamlined the dissection of promoters and the analysis of their regulatory elements. It is generally assumed that the vector has no influence on the activity of the promoter. This is a dangerous assumption because any 6-bp recognition sequence will occur on average approximately once every 4 kb, and more frequently, if as little as one deviation from a pe...

NF- B and AP-1 Connection: Mechanism of NF- B-Dependent Regulation of AP-1 Activity

Alterations in AP-1 and AP-1 Regulatory Genes during HPV-Induced Carcinogenesis

BACKGROUND Previous studies demonstrated a functional involvement of the AP-1 transcription factor in HPV-induced cervical carcinogenesis. Here, we aimed to obtain further insight in expression alterations of AP-1 family members during HPV-mediated transformation and their relationship to potential regulatory (Notch1, Net) and target (CADM1) genes. METHODS mRNA expression levels of c-Jun, Jun...

Organ-specific distribution of AP-1 in AP-1 luciferase transgenic mice during the maturation process.

Activator protein-1 (AP-1), a dimeric complex consisting of proteins encoded by the jun and fos gene families, is a transcription factor induced by a variety of signals including those eliciting proliferation, differentiation, and neoplastic transformation. Although AP-1 has been widely studied in the last decade, physiological levels of AP-1 in different tissues are unclear. In the present stu...